Expanded View Figures HMGA 2 NFE 2 THAP 10 RERE HES 7 FOXP 1 RUNX 3 UBP 1 ZBTB 12 HOXC 6 HOXA 10
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The Oncogenic Potential of Deregulated Homeobox Genes1
Homeobox genes encode DNA-binding proteins that regulate gene expression during embryonic development. Deregulation of homeobox gene expression has been invoked as the molecular basis of a number of leukemias. We now demonstrate, using in vitro and in vivo transformation assays, that the overexpression of homeobox genes is the basis for transformation and tumorigenesis. Thus, clustered homeobox...
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In segmented organs, homeobox genes are involved in axial patterning and cell identity. Much less is known about their role in non-segmented endoderm derivatives such as the digestive epithelium. Using a xenograft model of fetal intestinal anlagen implanted under the skin of nude mice, we have investigated whether the expression of five homeobox genes (HoxA-4, HoxA-9, HoxC-8, Cdx-1 and Cdx-2) i...
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*Zejuan Li,1 *Hao Huang,1 *Yuanyuan Li,1 *Xi Jiang,1 Ping Chen,1 Stephen Arnovitz,1 Michael D. Radmacher,2 Kati Maharry,2 Abdel Elkahloun,3 Xinan Yang,4 Chunjiang He,1 Miao He,1 Zhiyu Zhang,5 Konstanze Dohner,6 Mary Beth Neilly,1 Colles Price,1 Yves A. Lussier,4 Yanming Zhang,1 Richard A. Larson,1 Michelle M. Le Beau,1 Michael A. Caligiuri,2 Lars Bullinger,6 Peter J. M. Valk,7 Ruud Delwel,7 Bob...
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Oxidation of molecular hydrogen catalyzed by [NiFe] hydrogenases is a widespread mechanism of energy generation among prokaryotes. Biosynthesis of the H2-oxidizing enzymes is a complex process subject to positive control by H2 and negative control by organic energy sources. In this report we describe a novel signal transduction system regulating hydrogenase gene (hox) expression in the proteoba...
متن کامل[Frontiers in Bioscience 11, 1607-1619, May 1, 2006] 1607 Insights into transcriptional regulation by FOXP3
1. Abstract 2. The Fox family of transcription factors 3. Fox Family Members in the Immune System 3.1. FoxD1/2 3.2. FoxN1 3.3. FoxJ1 3.4. FoxO 4. Discovery of the FoxP subfamily 5. Role of FOXP subfamily members in human disease 6. FoxP3: the black sheep of the FoxP subfamily 6.1 Identification of FoxP3 6.2. FoxP3 function 6.3. Role of transcriptional co-repressors in FoxP function 6.4. Structu...
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